Absence of the HIV-1 protective Delta ccr5 allele in most ethnic populations of India

Recent epidemiological data and projections indicate that HIV infection will spread rapidly in India. An allele Delta ccr5 of the beta-chemokine receptor gene CCR5 has been found to confer protection against HIV-1. We find that this protective allele is absent in most ethnic populations of India, ex...

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Bibliographic Details
Published inEuropean journal of human genetics : EJHG Vol. 9; no. 10; pp. 794 - 796
Main Authors Majumder, P P, Dey, B
Format Journal Article
LanguageEnglish
Published England 01.10.2001
Subjects
Alleles
Ethnic Groups - genetics
Female
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - ethnology
Genetic Predisposition to Disease - genetics
HIV Infections - epidemiology
HIV Infections - ethnology
HIV Infections - genetics
Humans
India - epidemiology
Male
Receptors, CCR5 - genetics
India
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Summary:Recent epidemiological data and projections indicate that HIV infection will spread rapidly in India. An allele Delta ccr5 of the beta-chemokine receptor gene CCR5 has been found to confer protection against HIV-1. We find that this protective allele is absent in most ethnic populations of India, except some populations of the northern and western regions where this allele may have been introduced by Caucasian gene flow. The implications of this finding are discussed in the light of increasing HIV prevalence in India.
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ISSN:1018-4813
1476-5438
DOI:10.1038/sj.ejhg.5200705