Gelatin-based extracellular matrix cryogels for cartilage tissue engineering

[Display omitted] In this study, gelatin-based cryogels were fabricated by mixing methacrylated gelatin (GelMA) with methacrylated hyaluronic acid (MeHA) or methacrylated chondroitin sulfate (MeCS) for cartilage tissue engineering. In vitro revealed that MeCS incorporated gelatin-based cryogel (G-Me...

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Published inJournal of industrial and engineering chemistry (Seoul, Korea) Vol. 45; pp. 421 - 429
Main Authors Han, Min-Eui, Kang, Byung Jae, Kim, Su-Hwan, Kim, Hwan D., Hwang, Nathaniel S.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 25.01.2017
한국공업화학회
Subjects
Cartilage
Chondroitin sulfate
Cryogel
Osteochondral
Tissue engineering
화학공학
Cartilage
Osteochondral
Chondroitin sulfate
Tissue engineering
Cryogel
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Summary:[Display omitted] In this study, gelatin-based cryogels were fabricated by mixing methacrylated gelatin (GelMA) with methacrylated hyaluronic acid (MeHA) or methacrylated chondroitin sulfate (MeCS) for cartilage tissue engineering. In vitro revealed that MeCS incorporated gelatin-based cryogel (G-MeCS) showed significant cartilaginous tissue stimulation. Furthermore, the cell-laden gelatin-based ECM cryogels were implanted into mouse subcutaneous tissue for 6weeks and displayed uniform distribution of cells with normal phenotype maintenance. Finally, when these cryogels were implanted into osteochondral defect of New Zealand white rabbit, full integration with host tissue and increased cellularity were observed with G-MeCS cryogel.
Bibliography:G704-000711.2017.45..007
ISSN:1226-086X
1876-794X
DOI:10.1016/j.jiec.2016.10.011