2-Nitropropane induces DNA repair synthesis in rat hepatocytes in vitro and in vivo

The genotoxicity of 2-nitropropane (2-NP) and 1-nitropropane (1-NP) was investigated by measuring the induction of DNA repair synthesis in rat liver cells in vitro and in vivo. 2-NP strongly induced DNA repair synthesis in both cases. When applied in vivo, 2-NP was considerably more effective in hep...

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Published inCarcinogenesis (New York) Vol. 9; no. 5; p. 811
Main Authors Andrae, U, Homfeldt, H, Vogl, L, Lichtmannegger, J, Summer, K H
Format Journal Article
LanguageEnglish
Published England 01.05.1988
Subjects
Alkanes - toxicity
Animals
Biotransformation
Cell Line
DNA Repair - drug effects
Female
Liver - drug effects
Male
Mutagens
Nitroparaffins - metabolism
Nitroparaffins - toxicity
Propane - analogs & derivatives
Propane - metabolism
Propane - toxicity
Rats
Rats, Inbred Strains
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Summary:The genotoxicity of 2-nitropropane (2-NP) and 1-nitropropane (1-NP) was investigated by measuring the induction of DNA repair synthesis in rat liver cells in vitro and in vivo. 2-NP strongly induced DNA repair synthesis in both cases. When applied in vivo, 2-NP was considerably more effective in hepatocytes from males than in those from females. 1-NP was not active in vitro or in vivo. 2-NP and 1-NP did not induce repair in cell lines of extrahepatic origin derived from rat, mouse, hamster and man. The results are consistent with the reported carcinogenicity of 2-NP in rat liver and suggest that the formation of hepatocarcinomas by 2-NP is due to the generation of a genotoxic metabolite from 2-NP by liver-specific metabolism.
ISSN:0143-3334
DOI:10.1093/carcin/9.5.811