Solubility of oxcarbazepine in eight solvents within the temperature range T=(288.15–308.15)K

• Published in: The Journal of chemical thermodynamics Vol. 104; pp. 45 - 49
• Main Authors: Nam, Kyungwan, Ha, Eun-Sol, Kim, Jeong-Soo, Kuk, Do-Hoon, Ha, Dong-Hyeon, Kim, Min-Soo, Cho, Cheong-Weon, Hwang, Sung-Joo
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.01.2017
• Subjects: Correlation; Oxcarbazepine; Solubility; Oxcarbazepine; Correlation; Solubility
• ISSN: 0021-9614; 1096-3626
• DOI: 10.1016/j.jct.2016.09.011

•Solubility of oxcarbazepine in eight pure solvents was determined.•The solubility of oxcarbazepine was observed highest in tetrahydrofuran.•The measured solubility data were correlated well with the modified Apelblat equation in all solvents investigated. In this study, the solubility of oxcarbazepine in pure methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, acetone, acetonitrile, and tetrahydrofuran was analysed across the temperature range of 288.15–308.15K under atmospheric pressure by using a solid-liquid equilibrium method. The experimental values obtained data were correlated using the modified Apelblat model at each temperature. The mole fraction solubility of oxcarbazepine in all eight pure solvents increased gradually in a temperature-dependent manner. The highest mole fraction solubility of 3.08×10−3 at 308.15K was observed for tetrahydrofuran, followed by acetone (1.82×10−3 at 308.15K), acetonitrile (1.22×10−3 at 308.15K), methanol (1.11×10−3 at 308.15K), ethanol (6.17×10−4 at 308.15K), 1-butanol (6.17×10−4 at 308.15K), 1-propanol (6.16×10−4 at 308.15K), and 2-propanol (4.13×10−4 at 308.15K). The experimental solubility in all solvents correlated well with that calculated using the modified Apelblat equation across the temperature range of (288.15–308.15)K. Therefore, the experimental solubility and correlation equations established in this study could be useful during the crystallization/purification, pre-formulation, and formulation stages of oxcarbazepine production in laboratories and related industries.