Effect of pentoxifylline, a multidrug resistance reversal agent, on haemopoietic stem cell homing

This paper investigates the mechanism of mouse haemopoietic stem cell homing into the cytoskeleton depolymerising agent Pentoxifylline was used, and shown to inhibit stem cell homing. The inhibition was reversible after 6 hours. The results obtained suggest that the haemopoietic stem cell homing rec...

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Bibliographic Details
Published inCell biology international Vol. 18; no. 2; pp. 79 - 84
Main Authors Gude, R.P., Chitnis, M.P., Rao, S.G.A.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Oxford, UK Elsevier Ltd 01.02.1994
Blackwell Publishing Ltd
Elsevier
Subjects
Animals
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Bone Marrow Cells
Cell Movement - drug effects
Cells, Cultured
Female
Hematopoietic Stem Cells - drug effects
Hematopoietic Stem Cells - physiology
Male
Medical sciences
Mice
Mice, Inbred Strains
Pentoxifylline - pharmacology
Pentoxifylline - toxicity
Pharmacology. Drug treatments
Specific Pathogen-Free Organisms
Spleen - cytology
Cell culture
Stem cell
Migration
Rodentia
Enzyme inhibitor
Cell surface
Cell motility
Vertebrata
Mammalia
Mouse
Hematopoiesis
Multiple resistance
Bone marrow
Xanthine derivatives
Biological receptor
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Summary:This paper investigates the mechanism of mouse haemopoietic stem cell homing into the cytoskeleton depolymerising agent Pentoxifylline was used, and shown to inhibit stem cell homing. The inhibition was reversible after 6 hours. The results obtained suggest that the haemopoietic stem cell homing receptor is anchored to cytoskeletal support intracellularly.
Bibliography:ark:/67375/WNG-9V75S36B-L
istex:54C854FCDD5A489E96B62BD252367CB86D0FD491
ArticleID:CBIN199
ISSN:1065-6995
1095-8355
DOI:10.1006/cbir.1994.1045