Alkaline hydrolysis of P(VAc‐co‐MMA) particles for vascular embolization procedures

Poly(vinyl acetate) (PVAc)‐based particles are used in medical and biomedical applications, including vascular embolization (VE) procedures. However, to render the technique safer and reproducible, the hydrolysis of the microbeads must be performed in some applications in order to control the hydrop...

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Bibliographic Details
Published inJournal of applied polymer science Vol. 137; no. 42
Main Authors Azevedo, Gustavo Dias, Pinto, José Carlos
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 10.11.2020
Wiley Subscription Services, Inc
Subjects
alkaline hydrolysis
Biomedical materials
copolymerization
Embolization
Hydrolysis
Materials science
Nanoparticles
poly(vinyl acetate‐co‐methyl methacrylate)
Polymers
Polymethacrylic acid
Polymethyl methacrylate
Polyvinyl acetates
Statistical analysis
suspension polymerization
Vinyl acetate
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Summary:Poly(vinyl acetate) (PVAc)‐based particles are used in medical and biomedical applications, including vascular embolization (VE) procedures. However, to render the technique safer and reproducible, the hydrolysis of the microbeads must be performed in some applications in order to control the hydrophilicity of the material. For this reason, in the present work the alkaline hydrolysis of poly(vinyl acetate‐co‐methyl methacrylate)—P(VAc‐co‐MMA)—microbeads is investigated. The hydrolytic conversions of PVAc and poly(methacrylic acid) (PMMA) chains were evaluated in terms of the concentrations of methanol and acetate ions present in the reaction media, since these chemicals are by‐products of alkaline hydrolyses of the ester groups of the polymers. It was observed that all investigated variables (temperature, time, and alkaline concentration) exert important effects on the final extents of hydrolysis, although the occurrence of nonlinear synergetic effects imposes the use of multivariable statistical analyses for proper characterization of variable effects. Besides, given the heterogeneous nature of the reaction system and the higher resistance to hydrolysis offered by PMMA segments, the overall hydrolytic conversions of the microbeads were low, as required in VE procedures. Finally, hydrolyses of P(VAc‐co‐MMA) chains can also lead to cleavage of polymer chains, as confirmed by reduction of average molar masses of the analyzed materials.
Bibliography:Funding information
Conselho Nacional de Desenvolvimento Científico e Tecnológico
ISSN:0021-8995
1097-4628
DOI:10.1002/app.49298