Idiopathic normal pressure hydrocephalus, quantitative EEG findings, and the cerebrospinal fluid tap test: a pilot study

• Published in: Journal of clinical neurophysiology Vol. 31; no. 6; p. 594
• Main Authors: Seo, Jong-Geun, Kang, Kyunghun, Jung, Ji-Young, Park, Sung-Pa, Lee, Maan-Gee, Lee, Ho-Won
• Format: Journal Article
• Language: English
• Published: United States 01.12.2014
• Subjects: Aged; Brain - physiopathology; Brain Waves; Cerebrospinal Fluid Shunts; Electroencephalography; Female; Humans; Hydrocephalus, Normal Pressure - diagnosis; Hydrocephalus, Normal Pressure - physiopathology; Hydrocephalus, Normal Pressure - surgery; Intracranial Pressure; Male; Patient Selection; Pilot Projects; Predictive Value of Tests; Spinal Puncture
• ISSN: 1537-1603
• DOI: 10.1097/WNP.0000000000000105

In this pilot study, we analyzed relationships between quantitative EEG measurements and clinical parameters in idiopathic normal pressure hydrocephalus patients, along with differences in these quantitative EEG markers between cerebrospinal fluid tap test responders and nonresponders. Twenty-six idiopathic normal pressure hydrocephalus patients (9 cerebrospinal fluid tap test responders and 17 cerebrospinal fluid tap test nonresponders) constituted the final group for analysis. The resting EEG was recorded and relative powers were computed for seven frequency bands. Cerebrospinal fluid tap test nonresponders, when compared with responders, showed a statistically significant increase in alpha2 band power at the right frontal and centrotemporal regions. Higher delta2 band powers in the frontal, central, parietal, and occipital regions and lower alpha1 band powers in the right temporal region significantly correlated with poorer cognitive performance. Higher theta1 band powers in the left parietal and occipital regions significantly correlated with gait dysfunction. And higher delta1 band powers in the right frontal regions significantly correlated with urinary disturbance. Our findings may encourage further research using quantitative EEG in patients with ventriculomegaly as a potential electrophysiological marker for predicting cerebrospinal fluid tap test responders. This study additionally suggests that the delta, theta, and alpha bands are statistically correlated with the severity of symptoms in idiopathic normal pressure hydrocephalus patients.