C60 Fullerene as Promising Therapeutic Agent for the Prevention and Correction of Skeletal Muscle Functioning at Ischemic Injury

• Published in: Nanoscale research letters Vol. 12; no. 1; p. 115
• Main Authors: Nozdrenko, D. M., Zavodovskyi, D. O., Matvienko, T. Yu, Zay, S. Yu, Bogutska, K. I., Prylutskyy, Yu. I., Ritter, U., Scharff, P.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2017
• Subjects: Chemistry and Materials Science; Materials Science; Molecular Medicine; Nano Express; Nanochemistry; Nanoscale Science and Technology; Nanotechnology; Nanotechnology and Microengineering; Nanotechnology and Nanomaterials 2016; C; Biochemical analysis; Ischemia; fullerene; Skeletal muscle; Muscle contraction dynamics
• ISSN: 1931-7573; 1556-276X
• DOI: 10.1186/s11671-017-1876-4

The therapeutic effect of pristine C 60 fullerene aqueous colloid solution (C 60 FAS) on the functioning of the rat soleus muscle at ischemic injury depending on the time of the general pathogenesis of muscular system and method of administration C 60 FAS in vivo was investigated. It was found that intravenous administration of C 60 FAS is the optimal for correction of speed macroparameters of contraction for ischemic muscle damage. At the same time, intramuscular administration of C 60 FAS shows pronounced protective effect in movements associated with the generation of maximum force responses or prolonged contractions, which increase the muscle fatigue level. Analysis of content concentration of creatine phosphokinase and lactate dehydrogenase enzymes in the blood of experimental animals indicates directly that C 60 FAS may be a promising therapeutic agent for the prevention and correction of ischemic-damaged skeletal muscle function.