Metabolites Identification of Curcumin, Demethoxycurcumin and Bisdemethoxycurcumin in Rats After Oral Administration of Nanoparticle Formulations by Liquid Chromatography Coupled with Mass Spectrometry

Background: Curcuminoids are promising cancer chemopreventive agents. Curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are the major bioactive curcuminoids in turmeric. However, comprehensive metabolic studies of these three curcuminoids are still limited.

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Bibliographic Details
Published inWorld Journal of Traditional Chinese Medicine Vol. 2; no. 4; pp. 29 - 37
Main Authors Li, Rui, Wang, Qi, Fan, Jing-Ran, He, Jun-Bin, Qiao, Xue, Xiang, Cheng, Guo, De-An, Ye, Min
Format Journal Article
LanguageEnglish
Published Key Laboratory of Food Biotechnology of Sichuan Province, School of Bioengineering, Xihua University, Chengdu 610039, China%State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road,Beijing 100191, China%State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road,Beijing 100191, China 01.12.2016
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road,Beijing 100191, China
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China
Wolters Kluwer Medknow Publications
Subjects
Bisdemethoxycurcumin
Curcumin
Demethoxycurcumin
Metabolic pathway
Solid lipid nanoparticles
Demethoxycurcumin
Curcumin
Metabolic pathway
Solid lipid nanoparticles
Bisdemethoxycurcumin
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Summary:Background: Curcuminoids are promising cancer chemopreventive agents. Curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are the major bioactive curcuminoids in turmeric. However, comprehensive metabolic studies of these three curcuminoids are still limited.
ISSN:2311-8571
2311-8571
DOI:10.15806/j.issn.2311-8571.2016.0035