Biogenic and facile synthesis of selenium nanoparticles using Vaccinium arctostaphylos L. fruit extract and anticancer activity against in vitro model of breast cancer

Biogenic synthesis of selenium nanoparticles (SeNPs) using plant extracts has emerged as a promising alternative approach to traditional chemical synthesis. The current study aims to introduce a safe, low‐cost, and green synthesis of SeNPs using fresh fruit extract of Vaccinium arctostaphylos L. The...

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Published inCell biology international Vol. 46; no. 10; pp. 1612 - 1624
Main Authors Gharbavi, Mahmoud, Mousavi, Mousa, Pour‐Karim, Mahsa, Tavakolizadeh, Mahdi, Sharafi, Ali
Format Journal Article
LanguageEnglish
Published London Wiley Subscription Services, Inc 01.10.2022
Subjects
Antitumor activity
Biocompatibility
Breast cancer
cytotoxicity
Drug delivery
Fourier transforms
Fruits
green synthesis
Light scattering
Microscopy
Nanoparticles
Plant extracts
Scanning electron microscopy
Selenium
selenium nanoparticles
Size distribution
Spectrophotometry
Transmission electron microscopy
Vaccinium arctostaphylos
Vaccinium arctostaphylos L
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Summary:Biogenic synthesis of selenium nanoparticles (SeNPs) using plant extracts has emerged as a promising alternative approach to traditional chemical synthesis. The current study aims to introduce a safe, low‐cost, and green synthesis of SeNPs using fresh fruit extract of Vaccinium arctostaphylos L. The biogenic synthesis of SeNPs was confirmed by different analyses including ultraviolet‐visible spectrophotometry, Fourier transform infrared, and energy‐dispersive X‐ray. Also, the crystalline nature, size, and morphology of the obtained SeNPs were characterized by X‐ray diffraction, dynamic light scattering, field emission scanning electron microscopy, and transmission electron microscopy techniques. The SeNPs were successfully synthesized with fruit extract of V. arctostaphylos L. in a regular spherical form and narrow size distribution with suitable zeta‐potential values and exhibited appropriate biocompatibility. It revealed that the synthesized SeNPs can significantly inhibit the growth of 4T1 breast cancer cells with an IC50 of ∼84.19 ± 25.96 µg/ml after 72 h treatment. Overall, it can be concluded that the green synthesized SeNPs can be attractive, nontoxic, and eco‐friendly candidates for drug delivery or medicinal applications.
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ISSN:1065-6995
1095-8355
DOI:10.1002/cbin.11852