A rare case of metastatic uterine lymphoma in a renal transplant patient

• Published in: Radiology case reports Vol. 16; no. 12; pp. 3675 - 3679
• Main Authors: Mega, James, O'Brien, Victoria, Hammond, Nicholas, Aeum, Judy, Bunch, Kristen
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.12.2021; Elsevier
• Subjects: Case Report; Multifocal nodal diffuse large B-cell lymphoma; Post-transplant lymphoproliferative diseases; Renal transplant; Uterine lymphoma; Renal transplant; Uterine lymphoma; Multifocal nodal diffuse large B-cell lymphoma; Post-transplant lymphoproliferative diseases
• ISSN: 1930-0433; 1930-0433
• DOI: 10.1016/j.radcr.2021.08.061

Primary and disseminated lymphoma of the female reproductive tract are rare types of lymphoma. However, in the setting of solid organ transplant, recipients have an approximately doubled risk of acquiring and dying from malignancy. Multiple treatment modalities are available for post-transplant lymphoproliferative diseases (PTLD), including chemotherapy, radiotherapy, surgery, and immunosuppression radiotherapy. We report a case of a 61-year-old female with multifocal nodal diffuse large B-cell lymphoma and a history of a renal transplant secondary to IgA nephropathy who developed metastatic diffuse large B-cell lymphoma to the uterus. While the baseline incidence of PTLD is elevated when compared with lymphoma in the general population, metastatic uterine lymphoma is rare. Awareness of reproductive organ involvement by lymphomas and increased malignancy risk in organ transplant patients are important considerations for diagnostic evaluation, including radiologic assessment.