Correlation of serum anti-Müllerian hormone levels with positive in vitro fertilization outcome using a short agonist protocol

• Published in: Hormones (Athens, Greece) Vol. 16; no. 2; pp. 161 - 170
• Main Authors: Mantzavinos, Spyridon D., Vlahos, Nikolaos P., Rizos, Demetrios, Botsis, Demetrios, Sergentanis, Theodoros N., Deligeoroglou, Efthimios, Mantzavinos, Themistoklis
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2017
• Subjects: Adult; Anti-Mullerian Hormone - blood; Clinical Protocols; Endocrinology; Female; Fertilization in Vitro - statistics & numerical data; Gonadotropin-Releasing Hormone - agonists; Humans; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Outcome Assessment (Health Care) - statistics & numerical data; Pregnancy; Research Paper; Retrospective Studies; Greek population; IVF; Pregnancy rate; Short agonist protocol; Anti-Mullerian hormone
• ISSN: 1109-3099; 2520-8721
• DOI: 10.14310/horm.2002.1731

OBJECTIVE: We examined the predictive ability of anti-Müllerian hormone (AMH) for clinical pregnancy in women who underwent in vitro fertilization (IVF) cycles in a short agonist protocol. DESIGN: This is a retrospective cohort study of 222 women undergoing their first IVF attempt between June 2010 and March 2016. Multivariate logistic regression analysis was performed to evaluate the independent associations between clinical pregnancy and its possible predictors. RESULTS: 14.9% of cycles were cancelled, >3 oocytes were retrieved in 55.4% of cycles and embryo transfer was performed in 70.7% of cases. Live birth was the final outcome in 19.8% of subjects, miscarriage occurred in 4.1%, whereas no pregnancy occurred in the remaining 76.1% of the study sample. The number of oocytes, number of embryos, embryo transfer rate and pregnancy rates were positively associated with serum AMH concentrations (p <0.001, for each association). When analyzed by age quartiles, the overall association between AMH and clinical pregnancy rates was evident across all age strata. CONCLUSIONS: Serum AMH levels are a strong predictive marker of clinical pregnancy in women undergoing a short agonist IVF protocol. There is also a strong association with cancellation rate, number of oocytes retrieved, poor response (≤3 oocytes), number of embryos, embryo transfer rate and live birth rates.