Electrochemical DNA sensors for drug determination

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 221; p. 115058
• Main Authors: Evtugyn, G.A., Porfireva, A.V., Belyakova, S.V.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 30.11.2022
• Subjects: Anthracycline determination; Drug determination; Electrochemical DNA sensor; Electropolymerization; Redox active polymer; Drug determination; Anthracycline determination; Redox active polymer; Electropolymerization; Electrochemical DNA sensor
• ISSN: 0731-7085; 1873-264X
• DOI: 10.1016/j.jpba.2022.115058

In this review, recent achievements in the development of the DNA biosensors developed for the drug determination have been presented with particular emphasis to the main principles of their assembling and signal measurement approaches. The design of the DNA sensors is considered with characterization of auxiliary components and their necessity for the biosensor operation. Carbon nanomaterials, metals and their complexes as well as electropolymerized polymers are briefly described in the assembly of DNA sensors. The performance of the DNA sensors is summarized within 2017–2022 for various drugs and factors influencing the sensitivity and selectivity of the response are discussed. Special attention is paid to the mechanism of the signal generation and possible drawbacks in the analysis of real samples. •Electrochemical DNA sensors for drug determination are reviewed.•The assembling of the surface layer is considered.•Electrochemical sensing principles are discovered.•Performance of the DNA sensors is compared.