Multifunctional hydrogel platform for biofilm scavenging and O2 generating with photothermal effect on diabetic chronic wound healing

• Published in: Journal of colloid and interface science Vol. 617; pp. 542 - 556
• Main Authors: Wang, Qian, Qiu, Weiwang, Li, Mengna, Li, Na, Li, Xiaoran, Qin, Xiaohong, Wang, Xueli, Yu, Jianyong, Li, Faxue, Huang, Liqian, Wu, Dequn
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.07.2022
• Subjects: Antibacterial properties; Biofilm removal; Diabetic wound healing; O2 generation; Photothermal effect; Photothermal effect; Antibacterial properties; O2 generation; Biofilm removal; Diabetic wound healing
• ISSN: 0021-9797; 1095-7103
• DOI: 10.1016/j.jcis.2022.03.040

[Display omitted] Diabetic wound treatment remains a major challenge due to the difficulties of eliminating bacterial biofilm and relieving wound hypoxia. To address these issues simultaneously, a multifunctional Dex-SA-AEMA/MnO2/PDA (DSAMP) hydrogel platform was developed with excellent biocompatibility and porous structure. The hydrogel could absorb the exudate, maintain humidity and permeate oxygen, which was prepared by encapsulating polydopamine (PDA) and manganese dioxide (MnO2) into Dex-SA-AEMA (DSA) hydrogel by UV irradiation. With the addition of PDA, the DSAMP hydrogel was proved to eliminate the biofilm after NIR photodynamic therapy (PTT, 808 nm) irradiation at 54 °C. Furthermore, in order to mitigate hypoxia wound microenvironment, MnO2 nanoparticles were added to convert the endogenous hydrogen peroxide (H2O2) into oxygen (O2, 16 mg L−1). The diabetic wound in vivo treated by DSAMP hydrogel was completely healed on 14 days. It was revealed that the DSAMP hydrogel possessed a great potential as dressing for diabetic chronic wound healing.