Layered Double Hydroxides as Promising Excipients for Drug Delivery Purposes

• Published in: European journal of pharmaceutical sciences Vol. 165; p. 105922
• Main Authors: de Sousa, André Luiz Moreira Domingues, dos Santos, Widson Michael, de Souza, Myla Lôbo, Silva, Laysa Creusa Paes Barreto Barros, Yun, Adriana Eun He Koo, Aguilera, Cindy Siqueira Britto, Chagas, Beatriz de França, Rolim, Larissa Araújo, da Silva, Rosali Maria Ferreira, Neto, Pedro José Rolim
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.10.2021
• Subjects: Layered double hydroxides. Anionic clays. Drug delivery systems. Multicomponent system; Layered double hydroxides. Anionic clays. Drug delivery systems. Multicomponent system
• ISSN: 0928-0987; 1879-0720
• DOI: 10.1016/j.ejps.2021.105922

Layered Double Hydroxides (LDH) have received great attention in the development of drug carrier systems. LDHs have become intelligent excipients of high technological potential for the pharmaceutical industry due to their ability to intercalate biomaterials in the interlayer region, adsorb substances on its vast surface area, have flexible structure, swelling properties, high chemical and thermal stability, modulate drug release, have high biocompatibility and be easily synthesized. This article, using typical examples, mainly addresses the systems formed between LDHs and antimicrobial, antineoplastic and anti-inflammatory agents, which constitute the main pharmacological classes of wide interest due to the problems encountered with low solubility, control in administration, stability in body fluids and toxicity, among others. Additionally, the article also reports on the recent development of ternary or quaternary (multicomponent systems) compounds based on LDH, bringing the advantages of targeted therapy, improving the aqueous stability of nanohybrids and the performance of these inorganic carriers. [Display omitted]