Evolution of the nucleotide sequence of influenza virus RNA segment 7 during drift of the H3N2 subtype

The complete genetic information contained in the influenza virus RNA segment 7 of the A/Bangkok/1/79 (H3N2) strain has been cloned by in vitro synthesis of the complementary dsDNA and its insertion into plasmid pBR322. The nucleotide sequence of the viral RNA segment has been determined from the cD...

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Bibliographic Details
Published inGene Vol. 23; no. 2; pp. 233 - 239
Main Authors Ortín, J, Martínez, C, del Río, L, Dávila, M, López-Galíndez, C, Villanueva, N, Domingo, E
Format Journal Article
LanguageEnglish
Published Netherlands 01.08.1983
Subjects
Amino Acid Sequence
Base Sequence
Biological Evolution
DNA - genetics
Gene Frequency
influenza A virus
Influenza A virus - genetics
Influenza A Virus, H3N2 Subtype
RNA, Viral - genetics
Viral Matrix Proteins
Viral Proteins - genetics
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Summary:The complete genetic information contained in the influenza virus RNA segment 7 of the A/Bangkok/1/79 (H3N2) strain has been cloned by in vitro synthesis of the complementary dsDNA and its insertion into plasmid pBR322. The nucleotide sequence of the viral RNA segment has been determined from the cDNA insert. It is 1027 nucleotides long, and contains two open reading frames, as shown for other influenza virus strains. When compared with the previously published sequence for the A/Udorn/72 (H3N2) strain, 15 nucleotide exchanges are observed, most of them silent mutations, and only two causing amino acid changes in each of the M1 and M2 protein sequences.
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ISSN:0378-1119
DOI:10.1016/0378-1119(83)90055-0