Triterpenoid saponins with anti-myocardial ischemia activity from the whole plants of Clematis tangutica

Four new triterpenoid saponins named clematangosides A-D (1-4) along with six known saponins (5-10) were isolated from the whole plants of Clematis tangutica. Their structures were determined by extensive spectral analysis and chemical evidences. All saponins were evaluated for their protective effe...

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Published inPlanta medica Vol. 79; no. 8; p. 673
Main Authors Zhang, Wei, Yao, Min-Na, Tang, Hai-Feng, Tian, Xiang-Rong, Wang, Min-Chang, Ji, Lan-Ju, Xi, Miao-Miao
Format Journal Article
LanguageEnglish
Published Germany 01.05.2013
Subjects
Carbohydrate Conformation
Clematis - chemistry
Magnetic Resonance Spectroscopy
Myocardial Ischemia - drug therapy
Saponins - chemistry
Saponins - isolation & purification
Saponins - therapeutic use
Spectrometry, Mass, Electrospray Ionization
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - therapeutic use
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Summary:Four new triterpenoid saponins named clematangosides A-D (1-4) along with six known saponins (5-10) were isolated from the whole plants of Clematis tangutica. Their structures were determined by extensive spectral analysis and chemical evidences. All saponins were evaluated for their protective effects in hypoxia-induced myocardial injury model. Compounds 2-4, 6, and 10 exhibited anti-myocardial ischemia activities with ED50 values in the range of 75.77-127.22 µM.
ISSN:1439-0221
DOI:10.1055/s-0032-1328541