Nitration of catecholamines with nitrogen oxides in mild conditions: a hypothesis for the reactivity of NO in physiological systems

Dopamine, norepinephrine and epinephrine react at room temperature, in acetate buffer (36) with sodium nitrite or in non-deaerated phosphate buffer (pH 7.4) with NO. The corresponding 6-nitro derivatives are formed. Catecholamines react at pH 3–6 with sodium nitrite or in non-deaerated buffer (pH 7....

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Bibliographic Details
Published inTetrahedron letters Vol. 35; no. 39; pp. 7231 - 7232
Main Authors de la Bretèche, Marie-Laure, Servy, Claudine, Lenfant, Maryse, Ducrocq, Claire
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 26.09.1994
Elsevier
Subjects
Chemistry
Chemistry, Organic
Exact sciences and technology
Noncondensed benzenic compounds
Organic chemistry
Physical Sciences
Preparations and properties
Science & Technology
NITRIC-OXIDE
2-PHASE NITRATION
PHENOLS
KINETICS
Nitration
Dopamine
Nitrogen monoxide
Benzenic compound
Buffer solution
Diphenols
Aminophenols
Sodium Nitrites
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Summary:Dopamine, norepinephrine and epinephrine react at room temperature, in acetate buffer (36) with sodium nitrite or in non-deaerated phosphate buffer (pH 7.4) with NO. The corresponding 6-nitro derivatives are formed. Catecholamines react at pH 3–6 with sodium nitrite or in non-deaerated buffer (pH 7.4) with NO leading to the 6-nitro derivatives.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(94)85368-1