Assessment of phase angle as a novel indicator for sarcopenic obesity according to the ESPEN/EASO criteria in older adults with diabetes mellitus

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 123; p. 112412
• Main Authors: Hafızoğlu, Merve, Yıldırım, Hatice Kübra, Öztürk, Yelda, Şahiner, Zeynep, Karaduman, Didem, Atbaş, Cansu, Doğu, Burcu Balam, Halil, Meltem Gülhan, Cankurtaran, Mustafa, Balcı, Cafer
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2024; Elsevier Limited
• Subjects: Activities of daily living; Adults; Aged; Biomarkers; Body mass index; Chronic fatigue syndrome; Comorbidity; Criteria; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diagnosis; Electric currents; Electric Impedance; Female; Females; Frailty; Gastrointestinal surgery; Geriatric Assessment - methods; Geriatric Assessment - statistics & numerical data; Geriatrics; Grip strength; Hand Strength - physiology; Humans; Male; Malnutrition; Mental depression; Metabolism; Morbidity; Mortality; Muscle strength; Musculoskeletal system; Nutritional status; Obesity; Obesity - complications; Obesity - physiopathology; Older adults; Older people; Patients; Performance assessment; Phase angle; Phase shift; Reactance; Regression analysis; Sarcopenia; Sarcopenia - diagnosis; Sarcopenia - physiopathology; Sarcopenic obesity; Vitamin deficiency; Walking; Sarcopenic obesity; Phase angle; Older adults; Diabetes mellitus
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2024.112412

•Sarcopenic obesity (SO) is a clinical condition with worse clinical outcomes, increased mortality, and morbidity than sarcopenia.•The relationship between the BIA-derived phase angle (PhA) and sarcopenia is known, but the relationship between PhA and SO in older adults with type DM remains unclear.•BIA-derived PhA was significantly associated with SO, independent of age, female gender, MNA-sf scores, HbA1c level, and CCI scores.•PhA can be considered a potential biomarker for SO in older adults with type 2 DM. Sarcopenic obesity (SO) is a clinical condition in which sarcopenia and obesity occur together, and is associated with more poor clinical outcomes, increased mortality, and morbidity than sarcopenia. Phase angle (PhA), a parameter derived from bioimpedance analysis (BIA), provides data on cellular health, membrane integrity, and cellular function. This study aimed to evaluate the relationship between SO and PhA among older adults with type 2 diabetes mellitus (DM). We performed a cross-sectional study in a tertiary hospital, and all participants underwent a comprehensive geriatric assessment, the hand-grip strength test (HGST), the chair stand test (CST) for muscle strength evaluation, the 4-meter walking test, and the timed up-and-go (TUG) test for physical performance assessment. The diagnosis of SO was made according to the ESPEN/EASO criteria. The PhA was determined automatically by the BIA using resistance and reactance at 50 kHz for each participant. A total of 322 participants were included in the study. The mean age of the participants was 72.5 ±5.8, and 203 (63%) of them were female; 63 (19.6%) of them were sarcopenic obese. In multivariable logistic regression analyses, a significant relationship was found when the model was adjusted for age, female gender, MNA-sf scores, HbA1c level, and CCI scores (OR: 0.53, 95%CI: 0.29–0.98, P = 0.04). In ROC analyses, for PhA in predicting SO diagnosis, the AUC was 0.586 (95%CI: 0.505–0.678, P = 0.033). At the cut-off score 4.4, sensitivity was 57.1% and specificity was 61.4%; positive predictive value (PPV) was 26.5%; negative predictive value (NPV) was 85.5%. The study identified a significant relationship between SO and PhA among older adults with type 2 DM. However, larger prospective studies are needed to confirm the potential utility of PhA as a biomarker for SO.