Carcinogenicity of p-chloroaniline in rats and mice

• Published in: Food and chemical toxicology Vol. 29; no. 2; pp. 119 - 124
• Main Authors: Chhabra, R.S., Huff, J.E., Haseman, J.K., Elwell, M.R., Peters, A.C.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1991; New York, NY Elsevier Science
• Subjects: Adenoma - chemically induced; Adrenal Gland Neoplasms - chemically induced; Aniline Compounds - toxicity; Animals; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Carcinoma - chemically induced; Chemical agents; Female; Fibrosis; Liver Neoplasms, Experimental - chemically induced; Male; Medical sciences; Mice; Neoplasms, Experimental - chemically induced; Pheochromocytoma - chemically induced; Rats; Rats, Inbred F344; Sarcoma, Experimental - chemically induced; Spleen - pathology; Splenic Neoplasms - chemically induced; Tumors; PCA; Chemical industry; Dyes; Rat; Toxicity; Rodentia; Oral administration; Long term; Carcinogen; Vertebrata; Mammalia; Amine; Mouse; Animal
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/0278-6915(91)90166-5

p-Chloroaniline (PCA), a dye intermediate, was evaluated for potential long-term toxicity and carcinogenicity. Groups of 50 F344/N rats of each sex were given by gavage PCA hydrochloride in deionized water at doses of 0, 2, 6 or 18 mg/kg body weight, 5 days/wk for 103 wk. Groups of 50 male and female B6C3F 1 mice of each sex were given 0, 3, 10 or 30 mg/kg on the same schedule. In general, body weights and survival were unaffected by PCA administration. In rats the group given 18 mg/kg had mild haemolytic anaemia and slight increases in methaemoglobin at various times during the study. Fibrosis of the spleen was significantly increased in all PCA-treated groups of male rats and in the 18-mg/kg group of female rats. Sarcomas of the spleen occurred in male rats, their incidence being 0 49 , 1 50 , 3 50 and 38 50 in control low-, mid- and high-dose groups, respectively. There was a slightly increased incidence of pheochromocytomas of the adrenal gland in both male and female rats. Dosed groups of male mice had increased incidences of hepatocellular adenomas or carcinomas ( 11 50 , 21 49 , 20 50 and 21 50 in controls, low- mid- and high-dose groups, respectively). Haemangiosarcomas of the liver or spleen were also increased in the high-dose group (incidences of 4 50 , 4 49 , 1 50 and 10 50 in controls, low-, mid- and high-dose groups, respectively). In conclusion, PCA was carcinogenic in male rats and male mice.