Oral vaccination with alginate microsphere systems

• Published in: Journal of controlled release Vol. 39; no. 2; pp. 209 - 220
• Main Authors: Bowersock, T.L., Hogenesch, H., Suckow, M., Porter, R.E., Jackson, R., Park, H., Park, K.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 01.05.1996; Elsevier
• Subjects: Alginate microsphere; Applied microbiology; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Microbiology; Mucosal immunity; Oral vaccination; Secretory IgA; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Secretory IgA; Mucosal immunity; Oral vaccination; Alginate microsphere; IgA; Immunization; Microsphere; Mucosa; Oral administration; Cellular immunity; Vaccine; Alginates; Oral cavity; Immunogenicity; Animal; Preparation; Mechanism of action; Humoral immunity
• ISSN: 0168-3659; 1873-4995
• DOI: 10.1016/0168-3659(95)00155-7

Oral vaccination is a simple, efficient way of inducing immunity at mucosal surfaces. The slow development of oral vaccines has been mainly due to the lack of suitable delivery systems. We have used hydrogel microspheres to deliver various vaccines to several animal species by oral administration. Oral delivery of vaccines using alginate microspheres elicited the production of secretory IgA (sIgA) at the mucosal surfaces in mice, rabbits, and cattle. Oral vaccination of chicken resulted in an increased delayed-type hypersensitivity, a cell-mediated immune response, indicating a positive response to the vaccine. Our studies have clearly shown that alginate microspheres are effective for the oral administration of vaccines.