Schiff base nanoarchitectonics for supramolecular assembly of dipeptide as drug carriers

[Display omitted] Development of peptide-based supramolecular materials with hierarchical morphology and tunable guest loading displays broad potential as drug carrier in view of biocompatibility and biodegradability. Herein, we report a facile Schiff base nanoarchitectonic for supramolecular assemb...

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Published inJournal of colloid and interface science Vol. 630; pp. 161 - 169
Main Authors Wu, Aoli, Guo, Yongxian, Li, Xianbao, Li, Qi, Chen, Guixin, Zang, Hengchang, Li, Junbai
Format Journal Article
LanguageEnglish
Published Elsevier Inc 15.01.2023
Subjects
Autofluorescence
Dipeptide
Drug carrier
Schiff base
Supramolecular gel
Dipeptide
Schiff base
Drug carrier
Supramolecular gel
Autofluorescence
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Summary:[Display omitted] Development of peptide-based supramolecular materials with hierarchical morphology and tunable guest loading displays broad potential as drug carrier in view of biocompatibility and biodegradability. Herein, we report a facile Schiff base nanoarchitectonic for supramolecular assembly of diphenylalanine (FF) metastable gel. The addition of trace glutaraldehyde (GA)/H2O solution induces the Schiff base reaction between GA and FF accompanying by phase transition from gel to solution. FF nanoparticles and hierarchical beaded nanofibers with autofluorescence properties can be constructed by regulating the competitive assembly between FF-H2O and FF-GA oligomer. Moreover, various guest molecules with different hydrophilic and hydrophobic properties can be easily loaded into such assembled particles and its release can be triggered under weak alkaline conditions, which show the potential application of the assembled FF system as drug carriers.
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ISSN:0021-9797
1095-7103
DOI:10.1016/j.jcis.2022.09.122