Sleep electroencephalographic abnormalities in adolescent depressives : Effects of scopolamine

In contrast to sleep studies of adult depressives that have consistently demonstrated abnormalities of sleep continuity, slow-wave sleep, and REM sleep, existing studies of depressed children and adolescents have been conflicting. Furthermore, only one study has explored the cholinergic regulation o...

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Published inBiological psychiatry (1969) Vol. 42; no. 7; pp. 577 - 584
Main Authors MCCRACKEN, J. T, POLAND, R. E, LUTCHMANSINGH, P, EDWARDS, C
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Science 01.10.1997
Subjects
Adolescent
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Child
Depression
Depressive Disorder - psychology
Electroencephalography - drug effects
Humans
Medical sciences
Mood disorders
Muscarinic Antagonists
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Scopolamine Hydrobromide
Sleep Stages - drug effects
Sleep, REM - drug effects
Suicide - psychology
Human
Mood disorder
Sleep stage
Adolescent
Sleep disorder
Depression
Electroencephalography
Neurotransmission
Cholinergic transmission
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Summary:In contrast to sleep studies of adult depressives that have consistently demonstrated abnormalities of sleep continuity, slow-wave sleep, and REM sleep, existing studies of depressed children and adolescents have been conflicting. Furthermore, only one study has explored the cholinergic regulation of sleep in early-onset depressives. In the present study, the electroencephalographic sleep of 20 adolescent outpatients with major depressive episodes and 13 normal control adolescents was obtained on two separate 2-night sessions, 1 night incorporating challenge with scopolamine. Depressed adolescents showed increased baseline phasic REM sleep measures, increased arousals, a trend toward reduced slow-wave sleep, and a greater difference in the change of first REM period density on the scopolamine night versus placebo night compared to controls. These findings support the continuity of some sleep abnormalities of depression into adolescence, and suggest that adolescent depression may be associated with alterations of cholinergic neurotransmission in some patients.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0006-3223
1873-2402
DOI:10.1016/S0006-3223(96)00431-3