Phototriggered delivery of hydrophobic carbonic anhydrase inhibitors

We have developed a versatile tool for the delivery of inhibitors of carbonic anhydrase II, which allows modification of a hydrophobic drug with either a water-solubilizing, photolabile cage or a hydrophobic. photolabile cage. The former mask is useful for direct delivery of hydrophobic molecules in...

Full description

Saved in:
Bibliographic Details
Published inPhotochemical & photobiological sciences Vol. 1; no. 10; pp. 774 - 779
Main Authors Kehayova, PD, Woodrell, CD, Dostal, PJ, Chandra, PP, Jain, A
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.10.2002
Subjects
Animals
Binding, Competitive
Biochemistry & Molecular Biology
Biophysics
Carbonic Anhydrase Inhibitors - administration & dosage
Chemistry
Chemistry, Physical
Drug Carriers - chemistry
Drug Carriers - radiation effects
Drug Delivery Systems
Eye Diseases - drug therapy
Humans
Hydrophobic and Hydrophilic Interactions
Life Sciences & Biomedicine
Light
Photolysis
Physical Sciences
Science & Technology
Spectrum Analysis
PRODRUG
DRUG-DELIVERY
Online AccessGet full text

Cover

More Information
Summary:We have developed a versatile tool for the delivery of inhibitors of carbonic anhydrase II, which allows modification of a hydrophobic drug with either a water-solubilizing, photolabile cage or a hydrophobic. photolabile cage. The former mask is useful for direct delivery of hydrophobic molecules in an aqueous prodrug form. The latter may find application if delivery from a surf-lice is desirable. In our system, where the target enzyme is found in the eye, both approaches may be useful for the delivery of hydrophobic drugs having subnanomolar dissociation constants from the enzyme.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1474-905X
1474-9092
DOI:10.1039/b200118g