Lack of interaction between sertraline and lamotrigine in psychiatric patients: a retrospective study

• Published in: Pharmacopsychiatry Vol. 45; no. 3; p. 119
• Main Authors: Christensen, J, Sandgaard, A P, Sidenius, P, Linnet, K, Licht, R W
• Format: Journal Article
• Language: English
• Published: Germany 01.05.2012
• Subjects: Adult; Anticonvulsants - administration & dosage; Anticonvulsants - blood; Anticonvulsants - pharmacokinetics; Antidepressive Agents - administration & dosage; Antidepressive Agents - blood; Antidepressive Agents - pharmacokinetics; Bipolar Disorder - drug therapy; Drug Interactions; Female; Humans; Male; Middle Aged; Retrospective Studies; Sertraline - administration & dosage; Sertraline - blood; Sertraline - pharmacokinetics; Triazines - administration & dosage; Triazines - blood; Triazines - pharmacokinetics
• ISSN: 1439-0795
• DOI: 10.1055/s-0031-1297975

This study evaluates the pharmacokinetic interaction between sertraline and lamotrigine in psychiatric patients. We identifi ed patients with at least 1 measurement of trough lamotrigine plasma concentration (at steady-state) during lamotrigine therapy and compared dose and plasma concentrations between patients who received lamotrigine with sertraline and patients who received lamotrigine without sertraline. The dose corrected concentration of lamotrigine in patients receiving lamotrigine in combination with sertraline was 60.4 μmol/L × 1,000/mg/day (SD: 31.1) (N = 7) compared to 51.1 μmol/L × 1 000/mg/day (SD: 27.6) (N = 44) in patients using lamotrigine without sertraline (p = 0.42). The slightly slower metabolism of lamotrigine in patients receiving lamotrigine with sertraline compared with those receiving lamotrigine alone is not believed to be of clinical signifi cance. However, due to the limited power, we may have overlooked a diff erence that could be clinically relevant.