BOP: Biocompatible osteoconductive polymer: An experimental approach

• Published in: Clinical materials Vol. 16; no. 4; pp. 217 - 221
• Main Authors: Buron, F., Bourgois, R., Burny, F., Chaboteaux, C., d'Hemricourt, J., El Banna, S., Pasteels, J.L., Sintzoff, S., Vienne, A.
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 1994; Oxford Elsevier
• Subjects: Animals; Biological and medical sciences; Biomechanical Phenomena; Calcium Gluconate - standards; Materials Testing; Medical sciences; Methylmethacrylates - standards; Nylons - standards; Osseointegration; Pyrrolidinones - standards; Rabbits; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; Biological properties; Nylon; Reticuloendothelial system; Methyl acrylate copolymer; Interaction; Diseases of the osteoarticular system; Radiologic investigation; Rabbit; Lagomorpha; Experimental study; Biomechanics; Vertebrata; Mammalia; Animal; Pyrrolidone(vinyl) copolymer; Biocompatibility; Biomaterial; Biomedical engineering
• ISSN: 0267-6605; 1878-6979
• DOI: 10.1016/0267-6605(94)90120-1

BOP (biocompatible osteoconductive polymer) is a material proposed for osteosyntheses and for filling of bone defects in orthopaedics, neurosurgery and stomatology. It is a composite made of a copolymer of N-vinylpyrrolidone and methylmethacrylate, of polyamide-6 fibers and of calcium gluconate. The histological investigation includes the study of 30 intact rabbit femurs instrumented with a BOP rod, as well as the study of organs of the reticuloendothelial system. The currently available results show the absence of toxicity on hematopoietic tissue. Zones of osteoblastic activity surround the rods, coupled with an osteoclastic reaction which may result in the partial fragmentation of the polyamide fibers and its incorporation in the newly formed bone. We also observed the encapsulation of the material. The biomechanical approach investigated the mechanical properties of the material in bending and in shear. The radiological aspects of the investigation consisted of computerized axial tomography of the implanted femurs to measure density at the bone-implant interface.