Xuebijing injection, a Chinese patent medicine, against severe pneumonia: Current research progress and future perspectives

Severe pneumonia is one of the most common infectious diseases and the leading cause of sepsis and septic shock. Preventing infection, balancing the patient’s immune status, and anti-coagulation therapy are all important elements in the treatment of severe pneumonia. As multi-target agents, Xuebijin...

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Published inJournal of integrative medicine Vol. 21; no. 5; pp. 413 - 422
Main Authors Zhang, Mei, Zheng, Rui, Liu, Wen-jing, Hou, Jun-ling, Yang, Yu-lei, Shang, Hong-cai
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2023
Subjects
Clinical trial
Pneumonia, bacterial
Pneumonia, viral
Severe pneumonia
Treatment mechanism
Xuebijing injection
Clinical trial
Xuebijing injection
Pneumonia, viral
Severe pneumonia
Pneumonia, bacterial
Treatment mechanism
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Summary:Severe pneumonia is one of the most common infectious diseases and the leading cause of sepsis and septic shock. Preventing infection, balancing the patient’s immune status, and anti-coagulation therapy are all important elements in the treatment of severe pneumonia. As multi-target agents, Xuebijing injection (XBJ) has shown unique advantages in targeting complex conditions and saving the lives of patients with severe pneumonia. This review outlines progress in the understanding of XBJ’s anti-inflammatory, endotoxin antagonism, and anticoagulation effects. From the hundreds of publications released over the past few years, the key results from representative clinical studies of XBJ in the treatment of severe pneumonia were selected and summarized. XBJ was observed to effectively suppress the release of pro-inflammatory cytokines, counter the effects of endotoxin, and assert an anticoagulation effect in most clinical trials, which are consistent with experimental studies. Collectively, this evidence suggests that XBJ could play an important and expanding role in clinical medicine, especially for sepsis, septic shock and severe pneumonia. Please cite this article as: Zhang M, Zheng R, Liu WJ, Hou JL, Yang YL, Shang HC. Xuebijing injection, a Chinese patent medicine, against severe pneumonia: Current research progress and future perspectives. J Integr Med. 2023; 21(5): 413–422.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2095-4964
DOI:10.1016/j.joim.2023.08.004