Will the polyphenol and adapalene combination be a good strategy on acne vulgaris?

Acne vulgaris is a common disease which affects about 85% of the population. Various topical drugs are available, but the retinoid derivatives are mostly taken into consideration. They are used as a first-line treatment drugs. However, they also have few side effects. Whereas, adapalene which is a t...

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Bibliographic Details
Published inMedical hypotheses Vol. 133; p. 109409
Main Authors Janani, S.K., Sureshkumar, Raman, Upadhyayula, Sai Surya Nikitha, Karthika, Chenmala, Vasanthi, C.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.12.2019
Subjects
Acne vulgaris
Nanaoemulgel
Polyphenol
Retinoid derivative
Synergistic effect
Acne vulgaris
Polyphenol
Synergistic effect
Retinoid derivative
Nanaoemulgel
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Summary:Acne vulgaris is a common disease which affects about 85% of the population. Various topical drugs are available, but the retinoid derivatives are mostly taken into consideration. They are used as a first-line treatment drugs. However, they also have few side effects. Whereas, adapalene which is a third generation topical retinoid has fewer side effects compared to other derivatives. In this, we hypothesize that the combination therapy of adapalene and flavonoid could improve the efficacy and thereby it can also decrease the treatment time. Since, flavonoids possess multiple activities we assume that it can improve the action of the drug by showing a synergistic activity. Moreover, when we incorporate these two drugs in nanoemulgel, it can easily penetrate into the skin and produce its therapeutic action. Hence, we assume that if this hypothesis proves to be correct then this method will be an effective one in treating acne (pustule).
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ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2019.109409