Reply to: “Comment on Choroidal Structural Analysis in Alzheimer Disease, Mild Cognitive Impairment, and Cognitively Healthy Controls”

• Published in: American journal of ophthalmology Vol. 225; pp. 208 - 209
• Main Authors: Robbins, Cason B., Greawl, Dilraj S., Thompson, Atalie C., Powers, James H., Soundararajan, Srinath, Koo, Hui Yan, Yoon, Stephen P., Polascik, Bryce W., Liu, Andy J., Agrawal, Rupesh, Fekrat, Sharon
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2021; Elsevier Limited
• Subjects: Alzheimer's disease; Biomarkers; Cognitive ability; Disease
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/j.ajo.2021.01.003

[...]it is possible that visual acuity (VA) measurements may be less reliable in individuals with Alzheimer disease (AD), because patients may have limited executive capacity to follow commands. There has been limited research regarding the optimal process for the measurement of VA in individuals with cognitive impairment; however, alternative methods may prove useful.1 Given the need for standardized measurements of VA across all groups, we elected to use Snellen distance corrected VA measurement. While image binarization may require more time and effort at present, the assessment of holistic choroidal variables including total choroidal area, luminal area, and choroidal vascularity index could be incorporated into future iterations of image review software.