Analysis of the physical characterization and the tabletability of calcium phosphate-based materials

• Published in: International journal of pharmaceutics Vol. 110; no. 1; pp. 37 - 45
• Main Authors: Muñoz-Ruiz, Angel, Payán Villar, Trinidad, Muñoz Muõz, Nuria, Monedero Perales, M.Carmen, Jiménez-Castellanos, M.Rosa
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 12.09.1994; Elsevier
• Subjects: Biological and medical sciences; Calcium phosphate-based material; Consolidation mechanism; Direct compression excipient; General pharmacology; Medical sciences; Particle size distribution; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Rheology; Tableting properties; Consolidation mechanism; Direct compression excipient; Tableting properties; Particle size distribution; Calcium phosphate-based material; Rheology; Calcium Phosphates; Particle size; Consolidation; Pharmaceutical technology; Vehicle(excipient); Dosage form; Tablet; Direct compression; Physical properties
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/0378-5173(94)90373-5

The rheological properties of the new excipients A-, Di- and Tri-tab® were in general better than those of Emcompress®, whereas a mixture of Emcompress® with magnesium stearate exhibited the best flow characteristics and the lowest coefficient of tablet weight variation. Granulometry of the xcipients demonstrates that Tri-tab® has a maximum mean diameter and a wide particle size distribution, while Emcompress® has a particle size distribution similar to that of Di-tab®. Different compression properties, namely, net work, compactibility, plasticity and ejection work were evaluated after adding a hydrophobic lubricant to the wall of the die. The compressional properties demonstrated the values of the friction parameters to be insufficient in the cae of Di- and Tri-tab® powders, therfore, lubrication would be a major factor in tableting with these excipients for direct compression. Absolutely different compressional behavior of Di-tabl was observed. Moreover, the parameters obtained from the Heckel in die tablet method were calculated in order to establish the comparative consolidation mechanisms in the excipients under study. Emcompress® showed a lower extent of brittle fracture and greater plasticity than the other calcium phosphate-based excipients.