Designs for mixture and process variables applied in tablet formulations

Although there are several methods for the construction of a design for process variables and mixture variables, there are not very many methods which are suitable to combine mixture and process variables in one design. Some of the methods which are feasible will be shown. These methods will be comp...

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Bibliographic Details
Published inAnalytica chimica acta Vol. 277; no. 2; pp. 455 - 465
Main Authors Duineveld, C.A.A., Smilde, A.K., Doornbos, D.A.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Amsterdam Elsevier B.V 28.05.1993
Elsevier
Subjects
Analysis
Biological and medical sciences
Design construction
General pharmacology
Medical sciences
Mixture variables
Optimization methods
Pharmaceuticals
Pharmacology. Drug treatments
Process variables
Design construction
Optimization methods
Mixture variables
Process variables
Pharmaceuticals
Process conditions
Statistical analysis
Experimental design
Tablet
Multivariate analysis
Pharmaceutical industry
Optimization
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Summary:Although there are several methods for the construction of a design for process variables and mixture variables, there are not very many methods which are suitable to combine mixture and process variables in one design. Some of the methods which are feasible will be shown. These methods will be compared in a design space consisting of three mixture variables and two process variables. This comparison will be made with criteria from the theory of optimal design and with the aid of experimental data.
ISSN:0003-2670
1873-4324
DOI:10.1016/0003-2670(93)80456-U