Excitatory action of some aspartate- and glutamate-containing dipeptides after intracerebroventricular injection in mice

The effects of some dipeptides, analogues of N-acetyl-alpha-L-aspartyl-L-glutamate, were studied after i.c.v. administration into mice in acute experiments. N-Acetyl-alpha-L-aspartyl-L-glutamate itself did not induce seizures in animals, but prevented glutamate-induced convulsions. All other dipepti...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 197; no. 2-3; p. 157
Main Authors Garyaev, A P, Dumpis, M A, Poznjakova, L N, Zaitzev, Y V, Piotrovsky, L B
Format Journal Article
LanguageEnglish
Published Netherlands 17.05.1991
Subjects
Animals
Anticonvulsants - pharmacology
Convulsants
Dipeptides - administration & dosage
Dipeptides - chemistry
Dipeptides - pharmacology
Glutamates - pharmacology
Injections, Intraventricular
Mice
Receptors, Amino Acid
Receptors, Cell Surface - drug effects
Receptors, Cell Surface - physiology
Seizures - chemically induced
Seizures - prevention & control
Structure-Activity Relationship
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Summary:The effects of some dipeptides, analogues of N-acetyl-alpha-L-aspartyl-L-glutamate, were studied after i.c.v. administration into mice in acute experiments. N-Acetyl-alpha-L-aspartyl-L-glutamate itself did not induce seizures in animals, but prevented glutamate-induced convulsions. All other dipeptides possessed excitatory glutamate-like actions. Some structural requirements for the excitatory effects of the dipeptides are discussed.
ISSN:0014-2999
DOI:10.1016/0014-2999(91)90515-R