Thalamic stimulation for disabling tremor in a patient with spinocerebellar degeneration

Thalamic stimulation alleviated coarse action tremor in a patient with spinocerebellar degeneration (SCD) and led to substantial improvement in daily functioning, though disability from ataxia remained. Intraoperative microrecording revealed a significant correlation between neuronal activity of the...

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Published inStereotactic and functional neurosurgery Vol. 83; no. 4; p. 131
Main Authors Shimojima, Yasuhiro, Hashimoto, Takao, Kaneko, Kazuma, Yazaki, Masahide, Yoshida, Kunihiro, Goto, Tetsuya, Yamada, Ryuzo, Hongo, Kazuhiro, Ikeda, Shu-ichi
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.2005
Subjects
Aged
Arm - physiopathology
Deep Brain Stimulation
Electromyography
Humans
Male
Neurons - physiology
Remission Induction
Spinocerebellar Degenerations - complications
Tremor - etiology
Tremor - therapy
Ventral Thalamic Nuclei - physiopathology
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Summary:Thalamic stimulation alleviated coarse action tremor in a patient with spinocerebellar degeneration (SCD) and led to substantial improvement in daily functioning, though disability from ataxia remained. Intraoperative microrecording revealed a significant correlation between neuronal activity of the ventral intermediate nucleus (Vim) and tremor electromyograms. The tremor-correlated activities of Vim neurons and abolition of the tremor by Vim stimulation suggest that Vim may be related to the generation of action tremor in SCD. Thalamic stimulation can be a useful treatment option for SCD patients with disabling tremor.
ISSN:1011-6125
DOI:10.1159/000088159