Macrophage polarization and signaling in diabetic kidney disease: a catalyst for disease progression

Diabetic kidney disease (DKD) is a serious complication of diabetes affecting millions of people worldwide. Macrophages, a critical immune cell type, are central players in the development and progression of DKD. In this comprehensive review, we delve into the intricate role of macrophages in DKD, e...

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Published inAmerican journal of physiology. Renal physiology Vol. 326; no. 3; pp. F301 - F312
Main Authors Youssef, Natalie, Noureldein, Mohamed H, Riachi, Mansour E, Haddad, Antony, Eid, Assaad A
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.03.2024
Subjects
Catalysts
Diabetes
Diabetes mellitus
Diabetes Mellitus - metabolism
Diabetic Nephropathies - metabolism
Disease Progression
Drug development
Humans
Immunosuppressive agents
Inflammation
Kidney diseases
Macrophage Activation
Macrophages
Macrophages - metabolism
Phenotypes
Polarization
Reviews
Signal Transduction
Therapeutic targets
Transcription factors
diabetic kidney disease
macrophages
polarization
inflammation
diabetes
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Summary:Diabetic kidney disease (DKD) is a serious complication of diabetes affecting millions of people worldwide. Macrophages, a critical immune cell type, are central players in the development and progression of DKD. In this comprehensive review, we delve into the intricate role of macrophages in DKD, examining how they can become polarized into proinflammatory M1 or anti-inflammatory M2 phenotypes. We explore the signaling pathways involved in macrophage recruitment and polarization in the kidneys, including the key cytokines and transcription factors that promote M1 and M2 polarization. In addition, we discuss the latest clinical studies investigating macrophages in DKD and explore the potential of hypoglycemic drugs for modulating macrophage polarization. By gaining a deeper understanding of the mechanisms that regulate macrophage polarization in DKD, we may identify novel therapeutic targets for this debilitating complication of diabetes. This review provides valuable insights into the complex interplay between macrophages and DKD, shedding light on the latest developments in this important area of research. This review aims to enhance understanding of the role that macrophages play in the pathogenesis of DKD.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.00266.2023