Antifungal Polyketides and Other Compounds from Amazonian Endophytic Talaromyces Fungi
The continuous search for biologically active compound candidates pushes the pursuit of new substances produced by diverse organisms. Endophytic fungi are known as a promising source of metabolites with several biological activities. Based on the rich Amazonian biodiversity and the chemical potentia...
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Published in | Journal of the Brazilian Chemical Society Vol. 29; no. 3; pp. 622 - 630 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English Portuguese |
Published |
SAO PAULO
Soc Brasileira Quimica
01.03.2018
Sociedade Brasileira de Química |
Subjects | |
Online Access | Get full text |
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Summary: | The continuous search for biologically active compound candidates pushes the pursuit of new substances produced by diverse organisms. Endophytic fungi are known as a promising source of metabolites with several biological activities. Based on the rich Amazonian biodiversity and the chemical potential of microbial sources, three Talaromyces strains, all major endophytes from their respective host plants, were studied aiming at the isolation of biologically active secondary metabolites. Through classical chromatographic approaches, 13 compounds were isolated from the antimicrobial extracts of the studied strains. From these, polyketides, steroids, anhydrides, and phenolic compounds were identified. Among them, two previously undescribed compounds were elucidated based on spectroscopic and spectrometric methods, a homodimer chromanone and a maleic anhydride methyl ester. The antimicrobial activity against a panel of pathogenic microorganisms from extracts, fractions, and isolated compounds was evaluated. |
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ISSN: | 0103-5053 1678-4790 1678-4790 |
DOI: | 10.21577/0103-5053.20170176 |