Inhibition of Zika Virus Replication by Synthetic Bis-Naphthoquinones

Zika virus (ZIKV) is a mosquito-borne pathogen which is a current global public health concern. There are currently no approved vaccines or antivirals against ZIKV infection. Taking into account that naphthoquinones have shown promising antiviral activity, the aim of this study was to describe the s...

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Published inJournal of the Brazilian Chemical Society Vol. 30; no. 8; pp. 1697 - 1706
Main Authors Gonzaga, Daniel T. G., Gomes, Rafaela S. P., Marra, Roberta K. F., da Silva, Fernando C., Gomes, Max W. L., Ferreira, Davis E., Santos, Raissa M. A., Pinto, Ana M., Ratcliffe, Norman Arthur, Cirne-Santos, Claudio C., Barros, Caroline S., Ferreira, Vitor F., Paixao, Izabel Christina N. P.
Format Journal Article
LanguageEnglish
Published SAO PAULO Soc Brasileira Quimica 01.08.2019
Sociedade Brasileira de Química
Subjects
Chemistry
CHEMISTRY, MULTIDISCIPLINARY
Physical Sciences
Science & Technology
IN-VITRO
bis-naphthoquinones
SCREEN
RNA
antiviral
DRUGS
Zika virus
INFECTION
Flavivirus
TYPE-2
arbovirus
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Summary:Zika virus (ZIKV) is a mosquito-borne pathogen which is a current global public health concern. There are currently no approved vaccines or antivirals against ZIKV infection. Taking into account that naphthoquinones have shown promising antiviral activity, the aim of this study was to describe the screening of two bis-naphthoquinones series against ZIKV. Twenty seven compounds were evaluated against ZIKV using Vero cells. The findings showed that among the compounds analyzed four were promising. Compound 3.3' -((2-nitrophenyl)methylene)bis(2-hydroxynaphthalene-1,4-dione) containing the nitro group at the ortho position showed the best selectivity index, followed by compound 3,3'-(4-chlorophenylmethylene)bis(naphthalene-1,2,4-triyl triacetate) with the chlorophenylmethylene radical. These results demonstrate that these bis-naphthoquinones are largely effective in inhibiting the replication of ZIKV.
ISSN:0103-5053
1678-4790
1678-4790
DOI:10.21577/0103-5053.20190071