Formation of formaldehyde in polyethyleneglycol and in poloxamer under stress conditions

Bendroflumethiazide (BFMT) hydrolyses to 5-trifluormethyl-2,4-disulfoamoylaniline (TFSA) and phenylacetaldehyde. In solid dispersions of BFMT in polyethylene glycol 6000 (PEG) and poloxamer 188 (PPEO) an unknown product was detected, isolated and identified as hydroflumethiazide (HFMT). HFMT was pro...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of pharmaceutics Vol. 114; no. 1; pp. 121 - 123
Main Authors Frontini, R., Mielck, J.B.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 31.01.1995
Elsevier
Subjects
Bendroflumethiazide
Biological and medical sciences
Degradation
Formaldehyde
Hydroflumethiazide
Medical sciences
Pharmacology. Drug treatments
Poloxamer
Polyethylene glycol
Urinary system
Degradation
Hydroflumethiazide
Bendroflumethiazide
Polyethylene glycol
Formaldehyde
Poloxamer
Diuretic
Ethylene oxide polymer
Stability
Sulfonamide
Solid dispersion
Thiazide
Degradation product
Physicochemical properties
Online AccessGet full text

Cover

More Information
Summary:Bendroflumethiazide (BFMT) hydrolyses to 5-trifluormethyl-2,4-disulfoamoylaniline (TFSA) and phenylacetaldehyde. In solid dispersions of BFMT in polyethylene glycol 6000 (PEG) and poloxamer 188 (PPEO) an unknown product was detected, isolated and identified as hydroflumethiazide (HFMT). HFMT was produced by the reaction of TFSA with formaldehyde being formed from PEG and from PPEO under stress conditions.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(94)00221-P