Alienusolin, a new 4α-deoxyphorbol ester derivative, and crotonimide C, a new glutarimide alkaloid from the Kenyan Croton alienus

• Published in: Planta medica Vol. 79; no. 18; p. 1762
• Main Authors: Ndunda, Beth, Langat, Moses K, Wanjohi, John M, Midiwo, Jacob O, Kerubo, Leonidah O
• Format: Journal Article
• Language: English
• Published: Germany 01.12.2013
• Subjects: Aedes - drug effects; Alkaloids - chemistry; Alkaloids - isolation & purification; Alkaloids - pharmacology; Animals; Anopheles - drug effects; Anti-Infective Agents - chemistry; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; Bacteria - drug effects; Benzamides - chemistry; Benzamides - isolation & purification; Benzamides - pharmacology; Cell Survival - drug effects; Cercopithecus aethiops; Croton - chemistry; Esters - chemistry; Esters - isolation & purification; Esters - pharmacology; Fungi - drug effects; Leishmania - drug effects; Medicine, African Traditional; Molecular Structure; Phorbol Esters - chemistry; Phorbol Esters - isolation & purification; Phorbol Esters - pharmacology; Phorbols - chemistry; Phorbols - isolation & purification; Phorbols - pharmacology; Piperidones - chemistry; Piperidones - isolation & purification; Piperidones - pharmacology; Plant Leaves - chemistry; Plant Roots - chemistry; Plants, Medicinal; Plasmodium falciparum - drug effects; Vero Cells
• ISSN: 1439-0221
• DOI: 10.1055/s-0033-1351044

Two novel compounds, alienusolin, a 4α-deoxyphorbol ester (1), crotonimide C, a glutarimide alkaloid derivative (2), and ten known compounds, julocrotine (3), crotepoxide (4), monodeacetyl crotepoxide (5), dideacetylcrotepoxide, (6), β-senepoxide (7), α-senepoxide (8), (+)-(2S,3R-diacetoxy-1-benzoyloxymethylenecyclohex-4,6-diene (9), benzyl benzoate (10), acetyl aleuritolic (11), and 24-ethylcholesta-4,22-dien-3-one (12) were isolated from the Kenyan Croton alienus. The structures of the compounds were determined using NMR, GCMS, and HRESIMS studies.