Design and synthesis of new potent human cytomegalovirus (HCMV) inhibitors based on internally hydrogen-bonded 1,6-naphthyridines

1,6-Naphthyridine-2-carboxylic acid benzylamides are potent anti-HCMV compounds. Replacement of the amide moiety by other groups containing internal hydrogen bonds was undertaken to extend the SAR. Our results indicated that the urca derivatives showed very good activity.

Saved in:
Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 11; no. 2; pp. 103 - 105
Main Authors CHAN, Laval, STEFANAC, Tomislav, LAVALLEE, Jean-Francois, JIN, Haolun, BEDARD, Jean, MAY, Suzanne, FALARDEAU, Guy
Format Journal Article
LanguageEnglish
Published Oxford Elsevier 22.01.2001
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - chemical synthesis
Antiviral Agents - pharmacology
Biological and medical sciences
Cell Survival - drug effects
Cytomegalovirus - drug effects
Drug Design
Hydrogen Bonding
Inhibitory Concentration 50
Medical sciences
Naphthalenes - chemistry
Naphthyridines - chemical synthesis
Naphthyridines - pharmacology
Pharmacology. Drug treatments
Structure-Activity Relationship
Thioamides - chemical synthesis
Thioamides - chemistry
Thioamides - pharmacology
Cytomegalovirus
Nitrogen heterocycle
Herpesviridae
Cytotoxicity
Betaherpesvirinae
In vitro
Biological activity
Virus
Bicyclic compound
Antiviral
Ureas
Naphtyridine derivatives
Chemical synthesis
Intramolecular hydrogen bond
Online AccessGet full text

Cover

More Information
Summary:1,6-Naphthyridine-2-carboxylic acid benzylamides are potent anti-HCMV compounds. Replacement of the amide moiety by other groups containing internal hydrogen bonds was undertaken to extend the SAR. Our results indicated that the urca derivatives showed very good activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)00607-7