Effects of GR203040, an NK1 antagonist, on radiation- and cisplatin-induced tissue damage in the ferret

• Published in: General pharmacology Vol. 31; no. 5; pp. 741 - 746
• Main Authors: ALFIERI, A. B, GARDNER, C. J
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier 01.11.1998
• Subjects: Animals; Antiemetics - pharmacology; Antineoplastic Agents - toxicity; Biological and medical sciences; Biological effects of radiation; Capillary Permeability - drug effects; Capillary Permeability - radiation effects; Cisplatin - toxicity; Drug toxicity and drugs side effects treatment; Duodenum - blood supply; Duodenum - drug effects; Duodenum - radiation effects; Ferrets; Fundamental and applied biological sciences. Psychology; Histocytochemistry; Jejunum - blood supply; Jejunum - drug effects; Jejunum - radiation effects; Kidney - blood supply; Kidney - drug effects; Kidney - radiation effects; Lung - blood supply; Lung - drug effects; Lung - radiation effects; Male; Medical sciences; Miscellaneous (drug allergy, mutagens, teratogens...); Neurokinin-1 Receptor Antagonists; Non ionizing radiations. Hertzian waves. Biooptics; Pharmacology. Drug treatments; Piperidines - pharmacology; Tetrazoles - pharmacology; Tissues, organs and organisms biophysics; Urinary Bladder - blood supply; Urinary Bladder - drug effects; Urinary Bladder - radiation effects; Whole-Body Irradiation; Fissipedia; Carnivora; Urinary system disease; NK1 Tachykinin receptor; Respiratory disease; Toxicity; Antiinflammatory agent; Inflammation; X ray irradiation; Cisplatin; Prevention; Vertebrata; Chemotherapy; Mammalia; Treatment; Animal; Ferret; Digestive diseases; Subcutaneous administration; Antagonist; Platinum II Complexes
• ISSN: 0306-3623; 1879-0011
• DOI: 10.1016/S0306-3623(98)00111-6

1. The effects of GR203040, a tachykinin neurokinin1 receptor antagonist, on tissue damage induced by X-irradiation (Rad) or cisplatin (Cisp) were investigated in ferrets. 2. GR203040 (0.3 mg/kg SC) reduced the Rad-induced plasma protein extravasation (PPE) in the duodenum and kidney by 25% in each tissue. 3. GR203040 (3 mg/kg SC, 5-min pretreatment and every 8 hr for 48 hr after Cisp) reduced the Cisp-induced PPE in the duodenum, jejunum and lung by 59, 52 and 60%, respectively. 4. Histological examination showed that GR203040 also ameliorated the Rad- and Cisp-induced tissue damage.