Synthesis of novel functionalized 5-nitroisoquinolines and evaluation of in vitro antimalarial activity

Novel aldimine and hydrazone isoquinoline derivatives were obtained after subjecting 1-formyl-5-nitroisoquinoline to classical reactions. Some of these compounds were found to have activity against a chloroquine-resistant Plasmodium falciparum strain (ACC Niger).

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Bibliographic Details
Published inEuropean journal of medicinal chemistry Vol. 30; no. 6; pp. 503 - 508
Main Authors Rathelot, P, Vanelle, P, Gasquet, M, Delmas, F, Crozet, MP, Timon-David, P, Maldonado, J
Format Journal Article
LanguageEnglish
Published PARIS CEDEX 15 Elsevier Masson SAS 1995
Elsevier
Subjects
aldimine
Antibiotics. Antiinfectious agents. Antiparasitic agents
antimalarial drug
Antiparasitic agents
Biological and medical sciences
Chemistry, Medicinal
hydrazone
isoquinoline
Life Sciences & Biomedicine
Medical sciences
Pharmacology & Pharmacy
Pharmacology. Drug treatments
Science & Technology
aldimine
isoquinoline
hydrazone
antimalarial drug
MALARIAL
ANTIMALARIAL DRUG
ALDIMINE
ISOQUINOLINE
HYDRAZONE
Antimalarial
Nitro compound
Isoquinoline derivatives
Structure activity relation
Parasiticid
Hydrazone
Chemical synthesis
In vitro
Aldimine
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Summary:Novel aldimine and hydrazone isoquinoline derivatives were obtained after subjecting 1-formyl-5-nitroisoquinoline to classical reactions. Some of these compounds were found to have activity against a chloroquine-resistant Plasmodium falciparum strain (ACC Niger).
ISSN:0223-5234
1768-3254
DOI:10.1016/0223-5234(96)88261-4