Matrix metalloproteinases in kidney homeostasis and diseases: an update

• Published in: American journal of physiology. Renal physiology Vol. 327; no. 6; pp. F967 - F984
• Main Authors: Tan, Roderick J., Liu, Youhua
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.12.2024
• Subjects: Animals; Extracellular Matrix - enzymology; Extracellular Matrix - metabolism; Extracellular Matrix - pathology; Homeostasis; Homeostasis - physiology; Humans; Kidney - enzymology; Kidney - metabolism; Kidney - pathology; Kidney - physiopathology; Kidney Diseases - enzymology; Kidney Diseases - metabolism; Kidney Diseases - pathology; Kidney Diseases - physiopathology; Matrix metalloproteinase; Matrix Metalloproteinases - metabolism; MMP; apoptosis; epithelial-mesenchymal transition; fibrosis; matrix; inflammation

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases with important roles in kidney homeostasis and pathology. While capable of collectively degrading each component of the extracellular matrix, MMPs also degrade nonmatrix substrates to regulate inflammation, epithelial plasticity, pro...