Matrix metalloproteinases in kidney homeostasis and diseases: an update

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases with important roles in kidney homeostasis and pathology. While capable of collectively degrading each component of the extracellular matrix, MMPs also degrade nonmatrix substrates to regulate inflammation, epithelial plasticity, pro...

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Published inAmerican journal of physiology. Renal physiology Vol. 327; no. 6; pp. F967 - F984
Main Authors Tan, Roderick J., Liu, Youhua
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.12.2024
Subjects
Animals
Extracellular Matrix - enzymology
Extracellular Matrix - metabolism
Extracellular Matrix - pathology
Homeostasis
Homeostasis - physiology
Humans
Kidney - enzymology
Kidney - metabolism
Kidney - pathology
Kidney - physiopathology
Kidney Diseases - enzymology
Kidney Diseases - metabolism
Kidney Diseases - pathology
Kidney Diseases - physiopathology
Matrix metalloproteinase
Matrix Metalloproteinases - metabolism
MMP
apoptosis
epithelial-mesenchymal transition
fibrosis
matrix
inflammation
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Summary:Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases with important roles in kidney homeostasis and pathology. While capable of collectively degrading each component of the extracellular matrix, MMPs also degrade nonmatrix substrates to regulate inflammation, epithelial plasticity, proliferation, apoptosis, and angiogenesis. More recently, intriguing mechanisms that directly alter podocyte biology have been described. There is now irrefutable evidence for MMP dysregulation in many types of kidney disease including acute kidney injury, diabetic and hypertensive nephropathy, polycystic kidney disease, and Alport syndrome. This updated review will detail the complex biology of MMPs in kidney disease.
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ISSN:1931-857X
1522-1466
1522-1466
DOI:10.1152/ajprenal.00179.2024