Effects of N-Butyl-2-Cyanoacrylate on High-Level Jejunojejunostomy

• Published in: European surgical research Vol. 44; no. 1; pp. 13 - 16
• Main Authors: Ensari, C.Ö., Genc, V., Cakmak, A., Erkek, B., Karayalcin, K.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2010
• Subjects: Anastomosis, Surgical; Animals; Enbucrilate - therapeutic use; Jejunum - surgery; Male; Original Paper; Postoperative Complications - prevention & control; Rats; Rats, Wistar; Tissue Adhesions - prevention & control; Adhesions; N-butyl-2-cyanoacrylate; Burst pressure; Anastomosis
• ISSN: 0014-312X; 1421-9921
• DOI: 10.1159/000257969

Background: Morbidity and mortality due to anastomotic complications in gastrointestinal surgery remain important problems. The tissue adhesive N-butyl-2-cyanoacrylate (NB2CA) is used in many fields of surgery. This study was designed to assess the effects of NB2CA on high-level jejunojejunostomy. Materials and Methods: Forty male albino Wistar rats were divided into 4 groups of 10 each. The groups were treated as follows: group 1 underwent only a jejunojejunostomy, group 2 underwent jejunojejunostomy followed by NB2CA application around the anastomosis, group 3 underwent jejunojejunostomy after a 60-min ischemia and a 60-min reperfusion, and group 4 underwent jejunojejunostomy after a 60-min ischemia and a 60-min reperfusion followed by NB2CA application around the anastomosis. At postoperative day 7, the subjects in all groups were sacrificed. Intra-abdominal adhesions, anastomotic complications and anastomotic burst pressures (ABP) were recorded. Results: The analysis of all the groups for adhesion scores and ABP showed statistical significance (p < 0.001). Conclusions: The use of NB2CA had positive effects in terms of increasing ABP both with and without the initial ischemia- reperfusion insult. However, it had the adverse effect of significantly increasing the number of intra-abdominal adhesions.