From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development

The hedgehog signalling pathway has been implicated in many different processes in fly and vertebrate development. It is now known that the hedgehog cascade is crucial for the patterning of the early respiratory system. Hedgehog signalling in the lung involves Gli transcription proteins, but their p...

Full description

Saved in:
Bibliographic Details
Published inRespiratory research Vol. 1; no. 1; pp. 30 - 35
Main Authors van Tuyl, M, Post, M
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 2000
BioMed Central
Subjects
Animals
Bone morphogenetic proteins
Drosophila
Embryo, Mammalian - physiology
Embryo, Nonmammalian
Fibroblast growth factors
Fruit-flies
Genetic transcription
Hedgehog Proteins
Humans
Lung - embryology
Mammals
Review
Signal Transduction - physiology
Trans-Activators - physiology
Online AccessGet full text

Cover

More Information
Summary:The hedgehog signalling pathway has been implicated in many different processes in fly and vertebrate development. It is now known that the hedgehog cascade is crucial for the patterning of the early respiratory system. Hedgehog signalling in the lung involves Gli transcription proteins, but their potential downstream target genes have yet to be identified. Bmp4 and Fgf10 have been shown to regulate lung branching morphogenesis but seem not to be targets of hedgehog signalling.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1465-9921
1465-993X
1465-993X
DOI:10.1186/rr9