Significance of 18 F-FDG PET and immunohistochemical GLUT-1 expression for cardiac myxoma

• Published in: Diagnostic pathology Vol. 9; no. 1; p. 117
• Main Authors: Okazaki, Yukio, Yamada, Sohsuke, Kitada, Shohei, Matsunaga, Iwao, Nogami, Eijirou, Watanabe, Teruo, Sasaguri, Yasuyuki, Honma, Yutaka, Itou, Tsuyoshi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.06.2014; BioMed Central
• Subjects: Analysis; Biomarkers, Tumor - analysis; Biopsy; Care and treatment; Diagnosis; Family medical history; Female; Fluorodeoxyglucose F18; Glucose; Glucose Transporter Type 1 - analysis; Heart Neoplasms - chemistry; Heart Neoplasms - diagnosis; Heart Neoplasms - diagnostic imaging; Heart Neoplasms - surgery; Hospitals; Humans; Immunohistochemistry; Letter to the Editor; Medical imaging; Middle Aged; Myxoma; Myxoma - chemistry; Myxoma - diagnosis; Myxoma - diagnostic imaging; Myxoma - surgery; Pathology; Patient outcomes; PET imaging; Positron-Emission Tomography; Predictive Value of Tests; Radiopharmaceuticals; Surgery; Tomography, X-Ray Computed; Treatment Outcome; Tumors
• ISSN: 1746-1596; 1746-1596
• DOI: 10.1186/1746-1596-9-117

Cardiac tumours are relatively rare and are difficult to diagnose merely with imaging techniques. We demonstrated an unusual case of left atrial myxoma, displaying the successful detection by positron emission tomography using 2-deoxy-2-[18 F] fluoro-D-glucose (18 F-FDG PET), correlated closely to more intense and enhanced immunoreactivity with glucose transporter-1 (GLUT-1) in a substantial number of cardiac myxoma cells. Further prospective studies are needed to validate the significance of 18 F-FDG PET findings for cardiac myxoma and the association with immunohistochemical GLUT-1 expression in its tumour cells, after collecting and investigating a larger number of surgical cases examined with both of them. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2991481941253449.