Preparation of isotopically labelled benzophenone-containing lipid analogues

Methods have been developed for isotopic labelling of the benzophenone‐containing cholesterol analogue 1 and the fatty acid analogue 2 by use of deuteriated sodium borohydride derivatives. These procedures avoid the commercial catalytic tritiation which had previously been used to obtain 3H‐1 and 3H...

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Bibliographic Details
Published inJournal of labelled compounds & radiopharmaceuticals Vol. 48; no. 11; pp. 781 - 788
Main Authors Wang, Pingzhen, Spencer, Thomas A.
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 15.10.2005
Wiley
Subjects
benzophenones
Biochemical Research Methods
Biochemistry & Molecular Biology
Biological and medical sciences
borohydrides
Chemistry
Chemistry, Analytical
Chemistry, Medicinal
cholesterol
Contrast media. Radiopharmaceuticals
deuteriation
fatty acids
Life Sciences & Biomedicine
Medical sciences
Pharmacology & Pharmacy
Pharmacology. Drug treatments
Physical Sciences
Science & Technology
deuteriation
benzophenones
borohydrides
cholesterol
fatty acids
Deuterium
Steroid
Benzene derivatives
Tritium
Hydrogen Isotopes
Sodium Tetrahydroborates
Fatty acids
Ketone
Deuteriation
Chemical synthesis
Labelled compound
Sterol
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Summary:Methods have been developed for isotopic labelling of the benzophenone‐containing cholesterol analogue 1 and the fatty acid analogue 2 by use of deuteriated sodium borohydride derivatives. These procedures avoid the commercial catalytic tritiation which had previously been used to obtain 3H‐1 and 3H‐2. Copyright © 2005 John Wiley & Sons, Ltd.
Bibliography:istex:CFA3D98F3EB5D359FA50FD1DB65CDED2F4F4886B
USPHS NIH - No. HL 67294
ArticleID:JLCR996
ark:/67375/WNG-0Z47M97D-S
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.996