Capillary gas chromatographic determination of epomediol in human plasma and urine using a rapid solid-phase extraction

A simple and precise method for the quantitation of epomediol in human plasma and urine is described. Each biological sample is added with the internal standard and applied directly to an Extrelut-1 solid-phase column. After absorption the column is eluted with chloroform and the eluate is evaporate...

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Bibliographic Details
Published inBiomedical chromatography Vol. 3; no. 5; p. 199
Main Authors Girometta, M A, Loschi, L, Ventura, P, Canali, S, Giachetti, C, Zanolo, G
Format Journal Article
LanguageEnglish
Published England 01.09.1989
Subjects
Bridged Bicyclo Compounds, Heterocyclic
Cholagogues and Choleretics - analysis
Cholagogues and Choleretics - blood
Cholagogues and Choleretics - urine
Chromatography, Gas - methods
Humans
Terpenes - blood
Terpenes - urine
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Summary:A simple and precise method for the quantitation of epomediol in human plasma and urine is described. Each biological sample is added with the internal standard and applied directly to an Extrelut-1 solid-phase column. After absorption the column is eluted with chloroform and the eluate is evaporated to dryness. The residue, reconstituted in ethanol, is analysed by capillary gas chromatography. No interferences from possible metabolites or endogenous constituents can be noted. The method has been applied to human pharmacokinetic studies: the results of a subacute administration to volunteers are presented.
ISSN:0269-3879
DOI:10.1002/bmc.1130030505