Macrophages and transplant rejection: a novel future target?

In this issue of Transplantation, Ma et al. describe the protective effect of administering the c-fms kinase inhibitor upon cellular rejection, suggesting an important pathogenic role for macrophages. In contrast, no effect upon the development of humerol rejection was evident. The role of macrophag...

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Bibliographic Details
Published inTransplantation Vol. 96; no. 11; p. 946
Main Authors Tse, George H, Hughes, Jeremy
Format Journal Article
LanguageEnglish
Published United States 15.12.2013
Subjects
Animals
Graft Rejection - immunology
Immunity, Cellular
Immunity, Humoral
Kidney Transplantation - adverse effects
Macrophages - immunology
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Summary:In this issue of Transplantation, Ma et al. describe the protective effect of administering the c-fms kinase inhibitor upon cellular rejection, suggesting an important pathogenic role for macrophages. In contrast, no effect upon the development of humerol rejection was evident. The role of macrophages in rejection is discussed.
ISSN:1534-6080
DOI:10.1097/TP.0b013e3182a4bf20