Hospital admissions due to adverse drug reactions

One hundred three (4.1%) of 2,499 patients hospitalized in a general medical ward were admitted because of an adverse drug reaction (ADR). Of 60 drugs involved, the most common were cardiac, antibiotic, and antineoplastic agents. The main reactions included skin rashes, bone marrow depression, arrhy...

Full description

Saved in:
Bibliographic Details
Published inThe American journal of the medical sciences Vol. 277; no. 1; p. 49
Main Authors Levy, M, Lipshitz, M, Eliakim, M
Format Journal Article
LanguageEnglish
Published United States 01.01.1979
Subjects
Adrenal Cortex Hormones - adverse effects
Adult
Aged
Analgesics - adverse effects
Anti-Bacterial Agents - adverse effects
Antineoplastic Agents - adverse effects
Arrhythmias, Cardiac - chemically induced
Digoxin - adverse effects
Drug Hypersensitivity - etiology
Drug-Related Side Effects and Adverse Reactions
Female
Heart Diseases - chemically induced
Hemorrhage - chemically induced
Hospitalization
Humans
Male
Middle Aged
Quinidine - adverse effects
Risk
Skin Diseases - chemically induced
Online AccessGet more information

Cover

More Information
Summary:One hundred three (4.1%) of 2,499 patients hospitalized in a general medical ward were admitted because of an adverse drug reaction (ADR). Of 60 drugs involved, the most common were cardiac, antibiotic, and antineoplastic agents. The main reactions included skin rashes, bone marrow depression, arrhythmia, bleeding, and heart failure. Five (4.9%) of the patients died and 11 (10.7%) had life-threatening reactions. Risk factors predisposing to admissions due to ADR were: female sex, decreased renal function, polypragmasia, and the underlying disease. Twenty-seven percent of the admissions could have been avoided by a more careful choice and dosage of drug.
ISSN:0002-9629
DOI:10.1097/00000441-197901000-00006